Impact of germline mutations in cancer-predisposing genes on long-term survival in patients with epithelial ovarian cancer.

ABSTRACT:

Background

Several clinical and tumour factors impact on ovarian cancer survival. It is important to evaluate if germline mutations impact long-term outcomes among patients with epithelial ovarian cancer.

Methods

We followed 1422 Ontario women with ovarian cancer. Clinical information was obtained from medical records and vital status was determined by registry linkage. Germline genetic testing was performed for 12 susceptibility genes. We estimated 20-year cancer-specific survival according to various factors.

Results

Twenty-year survival was inferior for women with serous cancers vs. other types (22.3% vs. 68.6%; P < 0.0001). Of the 1422 patients, 248 (17.4%) carried a germline mutation; 119 BRCA1; 75 BRCA2; 7 in a mismatch repair (MMR) gene and 47 in one of seven o

SUBMITTER: Kotsopoulos J 

PROVIDER: S-EPMC9428139 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature