Association of pre- and postoperative αKlotho levels with long-term remission after pituitary surgery for acromegaly.

ABSTRACT: Soluble αKlotho (sKl) is a disease-specific biomarker that is elevated in patients with acromegaly and declines after surgery for pituitary adenoma. Approximately 25% of patients do not achieve remission after surgery, therefore a risk stratification for patients early in the course of their disease may allow for the identification of patients requiring adjuvant treatment. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have been assessed as biomarker for disease activity, however the value of sKl as a predictive biomarker of surgical success has not been evaluated yet. In this study, we measured serum biomarkers before and after transsphenoidal pituitary surgery in 55 treatment-naïve patients. Based on biochemical findings at follow-up (7-16 years), we divided patients into t

SUBMITTER: Neidert MC 

PROVIDER: S-EPMC9428163 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature