Cell-Free Treatments: A New Generation of Targeted Therapies for Treatment of Ischemic Heart Disease.

ABSTRACT: Although recent progress in medicine has substantially reduced cardiovascular diseases (CVDs)-related mortalities, current therapeutics have failed miserably to be beneficial for all patients with CVDs. A wide array of evidence suggests that newly-introduced cell-free treatments (CFTs) have more reliable results in the improvement of cardiac function. The main regeneration activity of CFTs protocols is based on bypassing cells and using paracrine factors. In this article, we aim to compare various stem cell secretomes, a part of a CFTs strategy, to generalize their effective clinical outcomes for patients with CVDs. Data for this review article were collected from 70 published articles (original, review, randomized clinical trials (RCTs), and case reports/series studies done on human and a

SUBMITTER: Daneshi N 

PROVIDER: S-EPMC9428475 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature