Niche, not phylogeny, governs the response to oxygen availability among diverse Pseudomonas aeruginosa strains.

ABSTRACT: Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen, is a leading cause of chronic infection of airways in cystic fibrosis (CF) patients. Chronic infections typically arise from colonization by environmental strains, followed by adaptation of P. aeruginosa to the conditions within the CF airway. It has been suggested that oxygen availability can be an important source of selection causing trait changes associated with the transition to chronic infection, but little data exist on the response of P. aeruginosa to varying levels of oxygen. Here, we use a diverse collection of P. aeruginosa strains recovered from both CF patients and environmental sources to evaluate the role of oxygen availability in driving adaptation to the CF

SUBMITTER: Shewaramani S 

PROVIDER: S-EPMC9428489 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature