Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents.

ABSTRACT: Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO ₂) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.

SUBMITTER: Wood TC 

PROVIDER: S-EPMC9428501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature