Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC9428510 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yan Man M Zheng Minying M Niu Rui R Yang Xiaohui X Tian Shifeng S Fan Linlin L Li Yuwei Y Zhang Shiwu S
Frontiers in cell and developmental biology 20220817
Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As major components of the TME, tumor-associated neutrophils (TANs) promote tumor progression and metastasis through communication with multiple growth factors, chemokines, inflammatory factors, and other immune cells, which together establish an immunosuppressive TME. In this review, we describe the potential mechanisms b ...[more]