Increased COX-1 expression in benign prostate epithelial cells is triggered by mitochondrial dysfunction.

ABSTRACT:

Background

Prostatic inflammation is closely linked to the development and progression of benign prostatic hyperplasia (BPH). Clinical studies of non-steroidal anti-inflammatory drugs, which inhibit cyclooxygenase-2 (COX-2), targeting prostate inflammation patients with symptomatic BPH have demonstrated conflicting results, with some studies demonstrating symptom improvement and others showing no impact. Thus, understanding the role of the cyclooxygenases in BPH and prostatic inflammation is important.

Methods

The expression of COX-1 was analyzed in a cohort of donors and BPH patients by immunohistochemistry and compared to previously determined characteristics for this same cohort. The impact of mitochondrial dysfunction on COX-1 and COX-2 was determined in experiments trea

SUBMITTER: Hudson CN 

PROVIDER: S-EPMC9428567 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature