Improved induced innate immune response after cART initiation in people with HIV.

ABSTRACT:

Introduction

Impairment of the innate immune function may contribute to the increased risk of bacterial and viral infections in people with HIV (PWH). In this study we aimed to investigate the induced innate immune responses in PWH prior to and after initiation of combinational antiretroviral therapy (cART). Furthermore, we aimed to investigate if the induced innate immune responses before initiation of cART were associated with CD4+ T-cell recovery one year after initiating cART.

Material and method

The induced innate immune response was assessed by the TruCulture^® whole blood technique in 32 PWH before cART initiation and after 1, 6 and 12 months. To mimic bacterial and viral infections we used a panel of three stimuli (lipopolysaccharide (LPS), resiquimod (R848

SUBMITTER: Hove-Skovsgaard M 

PROVIDER: S-EPMC9428745 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature