Integration of OV6 expression and CD68⁺ tumor-associated macrophages with clinical features better predicts the prognosis of patients with hepatocellular carcinoma.

ABSTRACT:

Background

Reliable prognostic indicators for accurately predicting postoperative outcomes in Hepatocellular carcinoma (HCC) patients are lacking. Although cancer stem-like cells (CSCs) and tumor-associated macrophages (TAMs) in tumor microenvironment are implicated in the occurrence and development of HCC, whether the combination of CSC biomarkers and TAM populations could achieve better performance in predicting the prognosis of patients with HCC has been rarely reported.

Methods

A total of 306 HCC patients were randomly divided into the training and validation cohorts at a 1:1 ratio, and the expression of OV6 and CD68 was assessed using immunohistochemistry in HCC samples. The prognostic value of these biomarkers for post-surgical survival and recurrence were evaluated by

SUBMITTER: Wang MD 

PROVIDER: S-EPMC9428913 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature