Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis.

ABSTRACT:

Background

The noble gases argon and xenon are potential novel neuroprotective treatments for acquired brain injuries. Xenon has already undergone early-stage clinical trials in the treatment of ischaemic brain injuries, with mixed results. Argon has yet to progress to clinical trials as a treatment for brain injury. Here, we aim to synthesise the results of preclinical studies evaluating argon and xenon as neuroprotective therapies for brain injuries.

Methods

After a systematic review of the MEDLINE and Embase databases, we carried out a pairwise and stratified meta-analysis. Heterogeneity was examined by subgroup analysis, funnel plot asymmetry, and Egger's regression.

Results

A total of 32 studies were identified, 14 for argon and 18 for xenon, involving measuremen

SUBMITTER: Liang M 

PROVIDER: S-EPMC9428918 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature