Medication risks in older patients (70 +) with cancer and their association with therapy-related toxicity.

ABSTRACT:

Background

To evaluate medication-related risks in older patients with cancer and their association with severe toxicity during antineoplastic therapy.

Methods

This is a secondary analysis of two prospective, single-center observational studies which included patients ≥ 70 years with cancer. The patients' medication lists were investigated regarding possible risks: polymedication (defined as the use of ≥ 5 drugs), potentially inappropriate medication (PIM), and relevant potential drug-drug interactions (rPDDI). The risks were analyzed before and after start of cancer therapy. Severe toxicity during antineoplastic therapy was captured from medical records according to the Common Terminology Criteria for Adverse Events (CTCAE). The association between grade ≥ 3 toxicity and me

SUBMITTER: Ortland I 

PROVIDER: S-EPMC9429305 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature