Procalcitonin in early allograft dysfunction after orthotopic liver transplantation: a retrospective single centre study.

ABSTRACT:

Background

Ischemia-reperfusion injury (IRI) is the pathophysiological hallmark of hepatic dysfunction after orthotopic liver transplantation (OLT). Related to IRI, early allograft dysfunction (EAD) after OLT affects short- and long-term outcome. During inflammatory states, the liver seems to be the main source of procalcitonin (PCT), which has been shown to increase independently of bacterial infection. This study investigates the association of PCT, IRI and EAD as well as the predictive value of PCT during the first postoperative week in terms of short- and long-term outcome after OLT.

Methods

Patients ≥ 18 years undergoing OLT between January 2016 and April 2020 at the University Hospital of Zurich were eligible for this retrospective study. Patients with incomplete PCT d

SUBMITTER: Frick K 

PROVIDER: S-EPMC9429388 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature