Gut microbiome-targeted therapies in liver cirrhosis: a protocol for systematic review and meta-analysis.

ABSTRACT:

Background

Microbiome-targeted therapies (MTTs), including probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT), have been proposed as a potential treatment for cirrhosis via modulation of gut microbiome, while the impact of gut microflora alteration on liver function in cirrhosis trajectory is unclear, and no related systematic review has been published. We aim to comprehensively assess the effects of MTTs in patients with liver cirrhosis.

Methods

We will search databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) with no time restriction. Only randomized controlled trials published in English will be included. Two independent reviewers will be responsible for study identification and selection, data extraction

SUBMITTER: Jiang H 

PROVIDER: S-EPMC9429623 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature