An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke.

ABSTRACT:

Background

Ischemic stroke is one of the most serious global public health problems. However, the performance of current therapeutic regimens is limited due to their poor target specificity, narrow therapeutic time window, and compromised therapeutic effect. To overcome these barriers, we designed an ischemia-homing bioengineered nano-scavenger by camouflaging a catalase (CAT)-loaded self-assembled tannic acid (TA) nanoparticle with a M2-type microglia membrane (TPC@M2 NPs) for ischemic stroke treatment.

Results

The TPC@M2 NPs can on-demand release TA molecules to chelate excessive Fe²⁺, while acid-responsively liberating CAT to synergistically scavenge multiple ROS (·OH, ·O₂^-, and H₂O₂). Besides, the M2 microglia membra

SUBMITTER: Duan R 

PROVIDER: S-EPMC9429703 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature