Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice.

ABSTRACT:

Background

Asthma is a major public health problem worldwide. Emerging data from epidemiological studies show that allergies and allergic diseases may be linked to anxiety, depression and cognitive decline. However, little is known about the effect of asthma, an allergic lung inflammation, on cognitive decline/behavioral changes. Therefore, we investigated the hypothesis that allergic lung inflammation causes inflammation in the brain and leads to neurobehavioral changes in mice.

Methods

Wild-type C57BL/6J female mice were sensitized with nasal house dust mite (HDM) antigen or control PBS for 6 weeks to induce chronic allergic lung inflammation. A series of neurocognitive tests for anxiety and/or depression were performed before and after the intranasal HDM administration. A

SUBMITTER: Kanaya A 

PROVIDER: S-EPMC9429782 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature