Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.

ABSTRACT:

Background

Post-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The intestinal epithelial cells and microbiota reciprocally regulate each other in order to maintain intestinal homeostasis and control inflammation. However, a relative paucity of research has been focused on the host-derived regulatory network that controls mucin O-glycans and thereby changes gut microbiota during diarrhea in infancy. At the development stage just after birth, the ontogeny of intestinal epithelium, immune system, and gut microbiota appear similar in piglets and human infants. Here, we investigated the changes of mucin O-glycans associated with gut microbiota using a diarrheal post-weaned piglet model.

Results

We found tha

SUBMITTER: Xia B 

PROVIDER: S-EPMC9429786 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature