Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus.

ABSTRACT: Iron is essential to the virulence of Aspergillus species, and restricting iron availability is a critical mechanism of antimicrobial host defense. Macrophages recruited to the site of infection are at the crux of this process, employing multiple intersecting mechanisms to orchestrate iron sequestration from pathogens. To gain an integrated understanding of how this is achieved in aspergillosis, we generated a transcriptomic time series of the response of human monocyte-derived macrophages to Aspergillus and used this and the available literature to construct a mechanistic computational model of iron handling of macrophages during this infection. We found an overwhelming macrophage response beginning 2 to 4 h after exposure to the fungus, which included upregulated transcription of iron im

SUBMITTER: Adhikari B 

PROVIDER: S-EPMC9429928 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature