Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China.

ABSTRACT: Diarrhea is one of the most important problems associated with the production of piglets, which have a wide range of possible pathogens. This study identified a strain of porcine sapelovirus (PSV) by using next-generation sequencing (NGS) technologies as the pathogen among fecal samples in a pig herd. Phylogenetic analysis showed that the PSV isolates shared a unique polyprotein and clustered with Chinese isolates identified before 2013. The PSV strain was then isolated and named GS01. The in vitro and in vivo biological characteristics of this virus were then described. Our pathogenicity investigation showed that GS01 could cause an inflammatory reaction and induce serious diarrhea in neonatal piglets. To our knowledge, this is the first isolation and characterization of PSV

SUBMITTER: Chen J 

PROVIDER: S-EPMC9430179 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature