Locally superengineered cascade recognition-quantification zones in nanochannels for sensitive enantiomer identification.

ABSTRACT: As an intriguing and intrinsic feature of life, chirality is highly associated with many significant biological processes. Simultaneous recognition and quantification of enantiomers remains a major challenge. Here, a sensitive enantiomer identification device is developed on TiO₂ nanochannels via the design of cascade recognition-quantification zones along the nanochannels. In this system, β-cyclodextrin (β-CD) is self-assembled on one side of the nanochannels for the selective recognition of enantiomers; CuMOFs are designed as the target-responsive partners on the other side of the nanochannels for the quantification of enantiomers that pass through the nanochannels. As a proof-of-principle of the cascade design, arginine (Arg) enantiomers are tested as the identificatio

SUBMITTER: Guo J 

PROVIDER: S-EPMC9430310 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature