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Heavy water recycling for producing deuterium compounds.

ABSTRACT: Deuterium oxide (D₂O) is a special variety of water that serves as a crucial resource in a range of applications, but it is a costly and unusual resource. We therefore developed a new D₂O concentration system that combines a polymer electrolyte water electrolyzer and a catalytic combustor for recycling used D₂O. In this study, 1.6 L of used D₂O, with a concentration of 93.1%, was electrolyzed for 13.6 h to obtain 0.62 L of D₂O, with a concentration of 99.3%. In addition, the recombined water obtained by burning electrolytic gas using the catalytic combustor was also electrolyzed for 8.8 h to obtain 0.22 L of D₂O, with a concentration of 99.0%. The estimated separation factor of this electrolyzer at 25 °C was 3.6, which is very close to the equilibrium constant of the water/hydrogen isotope exchange reaction. Recycled D₂O was used as a deuterium source for the deuteration reaction of sodium octanoate, and 93.6% deuterated sodium octanoate was obtained. It is concluded that there were no impurities in the recycled D₂O that interfered with the deuteration reaction. These results can lead to the development of a cost-effective deuteration method for these materials.

SUBMITTER: Akutsu-Suyama K

PROVIDER: S-EPMC9430630 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Heavy water recycling for producing deuterium compounds.

Akutsu-Suyama Kazuhiro K Sajiki Hironao H Ueda Misaki M Asamoto Makiko M Tsutsumi Yasuyuki Y

RSC advances 20220831 38

Deuterium oxide (D2O) is a special variety of water that serves as a crucial resource in a range of applications, but it is a costly and unusual resource. We therefore developed a new D2O concentration system that combines a polymer electrolyte water electrolyzer and a catalytic combustor for recycling used D2O. In this study, 1.6 L of used D2O, with a concentration of 93.1%, was electrolyzed for 13.6 h to obtain 0.62 L of D2O, with a concen ...[more]

PMID: 36128371

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Project description:BackgroundSupply of choline is not guaranteed in current preterm infant nutrition. Choline serves in parenchyma formation by membrane phosphatidylcholine (PC), plasma transport of poly-unsaturated fatty acids (PUFA) via PC, and methylation processes via betaine. PUFA-PC concentrations are high in brain, liver and lung, and deficiency may result in developmental disorders. We compared different deuterated (D9-) choline components for kinetics of D9-choline, D9-betaine and D9-PC.MethodsProspective study (1/2021-12/2021) in 32 enterally fed preterm infants (28 0/7-32 0/7 weeks gestation). Patients were randomized to receive enterally a single dose of 2.7 mg/kg D9-choline-equivalent as D9-choline chloride, D9-phosphoryl-choline, D9-glycerophosphorylcholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-PC(D9-POPC), followed by blood sampling at 1 + 24 h or 12 + 60 h after administration. Plasma concentrations were analyzed by tandem mass spectrometry. Results are expressed as median (25th/75th percentile).ResultsAt 1 h, plasma D9-choline was 1.8 (0.9/2.2) µmol/L, 1.3 (0.9/1.5) µmol/L and 1.2 (0.7/1.4) µmol/L for D9-choline chloride, D9-GPC and D9-phosphoryl-choline, respectively. D9-POPC did not result in plasma D9-choline. Plasma D9-betaine was maximal at 12 h, with lowest concentrations after D9-POPC. Maximum plasma D9-PC values at 12 h were the highest after D9-POPC (14.4 (9.1/18.9) µmol/L), compared to the other components (D9-choline chloride: 8.1 [5.6/9.9] µmol/L; D9-GPC: 8.4 (6.2/10.3) µmol/L; D9-phosphoryl-choline: 9.8 (8.6/14.5) µmol/L). Predominance of D9-PC comprising linoleic, rather than oleic acid, indicated fatty-acyl remodeling of administered D9-POPC prior to systemic delivery.ConclusionD9-Choline chloride, D9-GPC and D9-phosphoryl-choline equally increased plasma D9-choline and D9-betaine. D9-POPC shifted metabolism from D9-betaine to D9-PC. Combined supplementation of GPC and (PO) PC may be best suited to optimize choline supply in preterm infants. Due to fatty acid remodeling of (PO) PC during its assimilation, PUFA co-supplementation with (PO) PC may increase PUFA-delivery to critical organs. This study was registered (22.01.2020) at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502.Study registrationThis study was registered at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502.

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Heavy water recycling for producing deuterium compounds.

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Heavy water recycling for producing deuterium compounds.

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