Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus.

ABSTRACT: A major feature of the pathogenicity of Staphylococcus aureus is its ability to secrete cytolytic toxins. This process involves the translocation of the toxins from the cytoplasm through the bacterial membrane and the cell wall to the external environment. The process of their movement through the membrane is relatively well defined, involving both general and toxin-specific secretory systems. Movement of the toxins through the cell wall was considered to involve the passive diffusion of the proteins through the porous cell wall structures; however, recent work suggests that this is more complex, and here we demonstrate a role for the wall teichoic acids (WTA) in this process. Utilizing a genome-wide association approach, we identified a polymorphism in the locus encoding the WTA biosynthe

SUBMITTER: Brignoli T 

PROVIDER: S-EPMC9430763 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature