Differential Expression of Two Copies of the irmA Gene in the Enteroaggregative E. coli Strain 042.

ABSTRACT: Gene duplications significantly impact the gene repertoires of both eukaryotic and prokaryotic microorganisms. The genomes of pathogenic Escherichia coli strains share a group of duplicated genes whose function is mostly unknown. The irmA gene is one of the duplicates encoded in several pathogenic E. coli strains. The function of its gene product was investigated in the uropathogenic E. coli strain CFT073, which contains a single functional copy. The IrmA protein structure mimics that of human interleukin receptors and likely plays a role during infection. The enteroaggregative E. coli strain 042 contains two functional copies of the irmA gene. In the present work, we investigated their biological roles. The irmA_4509 allele is expressed under several growth con

SUBMITTER: Bernabeu M 

PROVIDER: S-EPMC9431211 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature