Taxonomic and Functional Shifts in the Perinatal Gut Microbiome of Rhesus Macaques.

ABSTRACT: Pregnancy and the postpartum period result in some of the most dramatic metabolic, hormonal, and physiological changes that can be experienced by an otherwise healthy adult. The timing and magnitude of these changes is key for both maternal and fetal health. One of the factors believed to critically modulate these physiological changes is the maternal gut microbiome. However, the dynamic changes in this community during the perinatal period remain understudied. Clinical studies can be complicated by confounding variables like diet and other drivers of heterogeneity in the human microbiome. Therefore, in this study, we conducted a longitudinal analysis of the fecal microbiome obtained during the pregnancy and postpartum periods in 26 captive rhesus macaques using 16S rRNA gene amplicon sequ

SUBMITTER: Rhoades NS 

PROVIDER: S-EPMC9431225 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature