Focal non-invasive deep-brain stimulation with temporal interference for the suppression of epileptic biomarkers.

ABSTRACT:

Introduction

Neurostimulation applied from deep brain stimulation (DBS) electrodes is an effective therapeutic intervention in patients suffering from intractable drug-resistant epilepsy when resective surgery is contraindicated or failed. Inhibitory DBS to suppress seizures and associated epileptogenic biomarkers could be performed with high-frequency stimulation (HFS), typically between 100 and 165 Hz, to various deep-seated targets, such as the Mesio-temporal lobe (MTL), which leads to changes in brain rhythms, specifically in the hippocampus. The most prominent alterations concern high-frequency oscillations (HFOs), namely an increase in ripples, a reduction in pathological Fast Ripples (FRs), and a decrease in pathological interictal epileptiform discharges (IEDs).

Material

SUBMITTER: Acerbo E 

PROVIDER: S-EPMC9431367 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature