Discovery of Novel Iminosugar Compounds Produced by Lactobacillus paragasseri MJM60645 and Their Anti-Biofilm Activity against Streptococcus mutans.

ABSTRACT: The oral cavity contains a number of microbes. They interact with each other and play an important role in human health. Among oral cariogenic microbes, Streptococcus mutans is recognized a major etiological bacteria of dental caries. Lactobacilli strains have been promoted as possible probiotic agents against S. mutans. However, their inhibitory mechanism has not been well elucidated yet. In the present study, two new compounds with strong antibiofilm activities were purified from the culture supernatant of Lactobacillus paragasseri MJM60645, which was isolated from the human oral cavity. These compounds showed strong inhibitory activities against S. mutans biofilm formation, with IC₅₀ (concentration at which 50% biofilm was inhibited) of 30.4 μM for compound 1 and 18.9 μM for

SUBMITTER: Gu M 

PROVIDER: S-EPMC9431463 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature