Emergence and Evolution of Unique Plasmids Harboring bla_IMP-70 and bla_CTX-M-253 in Multidrug-Resistant Providencia rettgeri.

ABSTRACT: Although the prevalence of carbapenem-resistant Enterobacterales remains low in Japan, these bacteria are a growing problem worldwide, owing to their multidrug resistance phenotype. We isolated a multidrug-resistant Providencia rettgeri strain, NR1418, harboring a rare bla_IMP variant, bla_IMP-70, a novel bla_CTX-M variant, designated bla_CTX-M-253, and bla_MOX-1. This strain is resistant to β-lactams, amikacin, levofloxacin, and colistin. Genomic analysis revealed that NR1418 carries two plasmids, designated pNR1418-1 and pNR1418-2. The pNR1418-1 plasmid harbors bla_CTX-M-253, bla_TEM-1, and bla_MOX-1, while the pNR1418-2 plasmid harbors bla_IM

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC9431670 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature