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Electrochemically-promoted synthesis of benzo[b]thiophene-1,1-dioxides via strained quaternary spirocyclization† † Electronic supplementary information (ESI) available. CCDC 2044891, 2044867 and 2171791. For ESI and crystallographic data in CIF or other electronic format see https://doi.org/10.1039/d2sc01175a

ABSTRACT: We report an approach for the synthesis of benzothiophene motifs under electrochemical conditions by the reaction of sulfonhydrazides with internal alkynes. Upon the formation of a quaternary spirocyclization intermediate by the selective ipso-addition instead of an ortho-attack, the S-migration process was rationalized to lead to the products. Computational studies revealed the selectivity and the compatibility of drug molecules showcased the potential application of the protocols. We report an approach for the synthesis of benzothiophene motifs under electrochemical conditions by the reaction of sulfonhydrazides with internal alkynes.

SUBMITTER: Li R

PROVIDER: S-EPMC9431990 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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