Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial.

ABSTRACT:

Objective

To describe the effect of prednisolone on language in children with autism spectrum disorder. This study is based upon two hypotheses: autism etiology may be closely related to neuroinflammation; and, an effective treatment should restore the individual's language skills.

Method

This is a prospective, double-blinded, randomized, placebo-controlled clinical trial, carried out in a federal university hospital. The initial patient sample consisted of 40 subjects, which were randomized into two parallel groups. Inclusion criteria were: male gender, 3-7 years of age, and meeting the Diagnostic and Statistical Manual of Mental Disorders - 4th edition (DSM-IV) diagnostic criteria. The final sample consisted of 38 patients, of whom 20 were randomized to the placebo group a

SUBMITTER: Brito AR 

PROVIDER: S-EPMC9432069 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature