Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants.

ABSTRACT:

Objective

Mannose-binding lectin, which belongs to the collectin family, is an acute-phase reactant that activates the complement system. This study aimed to investigate the effect of MBL2 gene polymorphism on short-term outcomes in preterm infants.

Method

Infants of <37 gestational weeks who were admitted to the neonatal intensive care unit during a two-year period were enrolled in this prospective study. The neonates were categorized into two groups according to their MBL2 genotypes. Normal MBL2 genotype was defined as MBL2 wild-type (AA genotype), whereas mutant MBL2 genotype was defined as MBL2 variant-type (AO/OO genotype). The relationship between MBL2 genotype and short-term morbidity and mortality was evaluated.

Results

During the two-year study period, 116 pr

SUBMITTER: Dogan P 

PROVIDER: S-EPMC9432184 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature