IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis.

ABSTRACT:

Objectives

The study aimed to evaluate the link between the IL-4-C590T polymorphism and asthma susceptibility in children by meta-analysis.

Sources

The study collected all the case-control studies found in PubMed, Embase, CNKI, Wanfang, VIP, and other databases until September 2019. Stata v. 15.0 was used to conduct meta-analysis, calculate the combined OR and its 95% CI, and then conduct subgroup analysis.

Summary of the findings

Seven studies were included in the study, containing 860 cases and 810 controls. Relative to the C allele, the T allele at the IL-4-C590T locus was associated with susceptibility to asthma in children (OR = 1.45, 95% CI: 1.05-2.01). The results of ethnicity subgroup analysis showed that there was statistical significance, with OR = 1.61 (95%

SUBMITTER: Jin X 

PROVIDER: S-EPMC9432276 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature