Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.

ABSTRACT: The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors have increasingly come into focus, small non-coding RNAs have emerged as an essential component to disease etiology. Using Systemic RNA interference Defective (SID) mutants of the nematode Caenorhabditis elegans, deficient in gene silencing, we examined the potential consequences of dysfunctional epigenomic regulation in the context of Parkinson's disease (PD). Specifically, the loss of either the sid-1 or sid-3 genes, which encode a dsRNA transporter and an endocytic regulatory non-receptor tyrosine kinase, respectively, conferred neuroprotection to

SUBMITTER: Gaeta AL 

PROVIDER: S-EPMC9432717 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature