Prospective validation of a transcriptomic severity classifier among patients with suspected acute infection and sepsis in the emergency department.

ABSTRACT:

Background and importance

mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid and accurate prediction of severity in patients with suspected acute infections and sepsis remain an unmet need. IMX-SEV-2 is a 29-host-mRNA classifier designed to predict disease severity in patients with acute infection or sepsis.

Objective

Validation of the host-mRNA infection severity classifier IMX-SEV-2.

Design, settings and participants

Prospective, observational, convenience cohort of emergency department (ED) patients with suspected acute infections.

Outcome measures and analysis

Whole blood RNA tubes were analyzed using independently trained and validated composite target genes (IMX-SEV-2). IMX-SEV

SUBMITTER: Galtung N 

PROVIDER: S-EPMC9432813 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature