Rescue of the Congenital Hereditary Endothelial Dystrophy Mouse Model by Adeno-Associated Viruse-Mediated Slc4a11 Replacement.

ABSTRACT:

Purpose

Congenital hereditary endothelial dystrophy (CHED) is a rare condition that manifests at an early age showing corneal edema, increased oxidative stress, mitochondrial dysfunction, and eventually apoptosis of the endothelium due to loss of function of the membrane transport protein SLC4A11. This project tested whether replacing Slc4a11 into the Slc4a11 ^-/- CHED mouse model can reverse the disease-associated phenotypes.

Design

Experimental study.

Participants

Five-week-old or 11-week-old Slc4a11 ^-/- mice. Age- and gender-matched Slc4a11 ^+/+ animals were used as controls. A total of 124 animals (62 female, and 62 male) were used in this study. Fifty-three animals of the genotype Slc4a11 ^+/+<

SUBMITTER: Shyam R 

PROVIDER: S-EPMC9432820 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature