An extended and unified modeling framework for benchmark dose estimation for both continuous and binary data.

ABSTRACT: Protection and safety authorities recommend the use of model averaging to determine the benchmark dose approach as a scientifically more advanced method compared with the no-observed-adverse-effect-level approach for obtaining a reference point and deriving health-based guidance values. Model averaging however highly depends on the set of candidate dose-response models and such a set should be rich enough to ensure that a well-fitting model is included. The currently applied set of candidate models for continuous endpoints is typically limited to two models, the exponential and Hill model, and differs completely from the richer set of candidate models currently used for binary endpoints. The objective of this article is to propose a general and wide framework of dose response models, which

SUBMITTER: Aerts M 

PROVIDER: S-EPMC9432821 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature