Spatiotemporal NF-κB dynamics encodes the position, amplitude, and duration of local immune inputs.

ABSTRACT: Infected cells communicate through secreted signaling molecules like cytokines, which carry information about pathogens. How differences in cytokine secretion affect inflammatory signaling over space and how responding cells decode information from propagating cytokines are not understood. By computationally and experimentally studying NF-κB dynamics in cocultures of signal-sending cells (macrophages) and signal-receiving cells (fibroblasts), we find that cytokine signals are transmitted by wave-like propagation of NF-κB activity and create well-defined activation zones in responding cells. NF-κB dynamics in responding cells can simultaneously encode information about cytokine dose, duration, and distance to the cytokine source. Spatially resolved transcriptional analysis reveals that resp

SUBMITTER: Son M 

PROVIDER: S-EPMC9432835 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature