Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury.

ABSTRACT: Restoring limb movements after central nervous system injury remains a substantial challenge. Recent studies proved that crossing nerve transfer surgery could rebuild physiological connectivity between the contralesional cortex and the paralyzed arm to compensate for the lost function after brain injury. However, the neural mechanism by which this surgery mediates motor recovery remains still unclear. Here, using a clinical mouse model, we showed that this surgery can restore skilled forelimb function in adult mice with unilateral cortical lesion by inducing cortical remapping and promoting corticospinal tract sprouting. After reestablishing the ipsilateral descending pathway, resecting of the artificially rebuilt peripheral nerve did not affect motor improvements. Furthermore, retaining t

SUBMITTER: Gao Z 

PROVIDER: S-EPMC9432844 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature