Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.

ABSTRACT: Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanisms that underlie this integration are largely unknown. Here, we show that a wide range of states and stimuli converge upon a single Caenorhabditis elegans olfactory neuron to modulate food-seeking behavior. Using an unbiased ribotagging approach, we find that the expression of olfactory receptor genes in the AWA olfactory neuron is influenced by a wide array of states and stimuli, including feeding state, physiological stress, and recent sensory cues. We identify odorants that activate these state-depe

SUBMITTER: McLachlan IG 

PROVIDER: S-EPMC9433090 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature