Ontology highlight
ABSTRACT:
SUBMITTER: Mehta V
PROVIDER: S-EPMC9433096 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Mehta Ved V Khanppnavar Basavraj B Schuster Dina D Kantarci Ilayda I Vercellino Irene I Kosturanova Angela A Iype Tarun T Stefanic Sasa S Picotti Paola P Korkhov Volodymyr M VM
eLife 20220818
<i>Mycobacterium tuberculosis</i> adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane (TM) regions remains unknown. Here, we describe the cryo-EM structure of Cya bound to a stabilizing nanobody at 3.6 Å resolution. The TM helices 1-5 form a structurally conserved domain that facilita ...[more]