Sarcoid-like reaction in patients with malignant tumors: Long-term clinical course and outcomes.

ABSTRACT:

Background

The development of non-caseating epithelioid cell granulomas in cancer patients who do not fulfill the systemic sarcoidosis criteria is termed sarcoid-like reaction (SLR). Little is known about this condition's natural course and impact on the prognosis of malignancy. We aimed to investigate the natural course and prognostic value of cancer-associated SLR.

Methods

Clinical data were retrospectively analyzed in 32 patients with biopsy-proven cancer-associated SLR. Among patients with non-small cell lung cancer (NSCLC), SLR cases (n = 8) were matched with non-SLR cases (n = 78) for survival analysis.

Results

Among the included patients, the mean age was 59.7 years, and 68.8% were female. The median follow-up period was 35.6 months [interquartile

SUBMITTER: Huh JY 

PROVIDER: S-EPMC9433121 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature