Characteristics and Challenges of Primary Adrenal Insufficiency in Africa: A Review of the Literature.

ABSTRACT:

Backgrounds

Africa comprises 54 countries with varying degrees of economic development. As with other healthcare systems, rare diseases such as adrenal insufficiency are neglected and poorly documented.

Objectives

We wished to explore primary adrenal insufficiency (PAI) in Africa, its prevalence, aetiology, genetics, presentation, diagnosis, and treatment and to determine the unmet needs in clinical care, education, and research.

Materials and methods

A narrative nonsystematic review of the literature was undertaken. We searched two online databases (PubMed and Google scholar) using the search terms "Addison's disease/PAI, primary adrenal insufficiency coupled with "Africa," "country names," and "genetic disorders." A total of 184 PAI records were reviewed. The exclus

SUBMITTER: Mofokeng TRP 

PROVIDER: S-EPMC9433274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature