Brain-phenotype models fail for individuals who defy sample stereotypes.

ABSTRACT: Individual differences in brain functional organization track a range of traits, symptoms and behaviours^1-12. So far, work modelling linear brain-phenotype relationships has assumed that a single such relationship generalizes across all individuals, but models do not work equally well in all participants^13,14. A better understanding of in whom models fail and why is crucial to revealing robust, useful and unbiased brain-phenotype relationships. To this end, here we related brain activity to phenotype using predictive models-trained and tested on independent data to ensure generalizability¹⁵-and examined model failure. We applied this data-driven approach to a range of neurocognitive measures in a new, clinically and demographically heterogeneous dataset, wi

SUBMITTER: Greene AS 

PROVIDER: S-EPMC9433326 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature