In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts.

ABSTRACT: Historically, human breast cancer has been modeled largely in vitro using long-established cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of varying cellular and molecular complexities. A subset of cell line models has also been used in vivo as cell line-derived xenografts (CDX). While outstanding for conducting detailed molecular analysis of regulatory mechanisms that may function in vivo, results of drug response studies using long-established cell lines have largely failed to translate clinically. In an attempt to address this shortcoming, many laboratories have succeeded in developing clinically annotated patient-derived xenograft (PDX) models of human cancers, including breast, in a variety of host systems. While immunocompromised mice are the

SUBMITTER: Souto EP 

PROVIDER: S-EPMC9433358 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature