Comparative analysis of the molecular subtype landscape in canine and human mammary gland tumors.

ABSTRACT: Breast cancers in humans belong to one of several intrinsic molecular subtypes each with different tumor biology and different clinical impact. Mammary gland tumors in dogs are proposed as a relevant comparative model for human breast cancer; however, it is still unclear whether the intrinsic molecular subtypes have the same significance in dogs and humans. Using publicly available data, we analyzed gene expression and whole-exome sequencing data from 158 canine mammary gland tumors. We performed molecular subtyping using the PAM50 method followed by subtype-specific comparisons of gene expression characteristics, mutation patterns and copy number profiles between canine tumors and human breast tumors from The Cancer Genome Atlas (TCGA) breast cancer cohort (n = 1097). We found that lumina

SUBMITTER: Bergholtz H 

PROVIDER: S-EPMC9433360 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature