Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.

ABSTRACT: Bile acid (BA) homeostasis is regulated by the extensive cross-talk between liver and intestine. Many bile-acid-activated signaling pathways have become attractive therapeutic targets for the treatment of metabolic disorders. In this study we investigated the regulatory mechanisms of BA in the intestine. We showed that the BA levels in the gallbladder and faeces were significantly increased, whereas serum BA levels decreased in systemic Krüppel-like factor 9 (Klf9) deficiency (Klf9^-/-) mice. These phenotypes were also observed in the intestine-specific Klf9-deleted (Klf9^vil-/-) mice. In contrast, BA levels in the gallbladder and faeces were reduced, whereas BA levels in the serum were increased in intestinal Klf9 transgenic (Klf9^Rosa26+/+) mice. By using a

SUBMITTER: Liu S 

PROVIDER: S-EPMC9433408 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature