Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons.

ABSTRACT: The generation and differentiation of cortical projection neurons are extensively regulated by interactive programs of transcriptional factors. Here, we report the cooperative functions of transcription factors Bcl11a and Bcl11b in regulating the development of cortical projection neurons. Among the cells derived from the cortical neural stem cells, Bcl11a is expressed in the progenitors and the projection neurons, while Bcl11b expression is restricted to the projection neurons. Using conditional knockout mice, we show that deficiency of Bcl11a leads to reduced proliferation and precocious differentiation of cortical progenitor cells, which is exacerbated when Bcl11b is simultaneously deleted. Besides defective neuronal production, the differentiation of cortical projection neurons is bloc

SUBMITTER: Du H 

PROVIDER: S-EPMC9433425 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature