Psychiatric comorbidities and all-cause mortality in epilepsy: A nationwide cohort study.

ABSTRACT:

Background

People with epilepsy (PWE) having comorbid psychiatric conditions may be at greater risk of death. We aimed to determine the association between psychiatric disorders and all-cause mortality among PWE after adjustment for somatic comorbidities.

Methods

Based on data from the National Health Insurance Fund, a Cox survival analysis was done within a retrospective open cohort of all PWE (≥12 years) in Lithuania between January 2014 and June 2020. Cox models comparing mortality between PWE with or without psychiatric comorbidities were adjusted for sex, age, hospitalizations, and the epilepsy-specific comorbidity index.

Results

Of 47,964 PWE (age Md = 49, IQR = 34-62 years, 60.3% male, follow-up Md = 4.4, IQR = 2.1-6.1 years), 10,290 (21.5%) died during the stu

SUBMITTER: Puteikis K 

PROVIDER: S-EPMC9433706 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature