Colchicine as a novel drug for the treatment of osteosarcoma through drug repositioning based on an FDA drug library.

ABSTRACT:

Background

Colchicine is a traditional medication that is currently approved to treat gout and familial Mediterranean fever (FMF). However, colchicine has a wide range of anti-inflammatory activities, and several studies have indicated that it may be useful in a variety of other conditions, such as rheumatic disease, cardiac disease, and cancer. Osteosarcoma, the most common type of bone sarcoma, is derived from primitive bone-forming mesenchymal cells. In this study, we investigated whether colchicine could be used to treat osteosarcoma through the regulation of cell cycle signaling.

Methods

Two human osteosarcoma cell lines, U2OS and Saos-2, were used. A clonogenic assay was used to determine the antiproliferative effects of colchicine on osteosarcoma cells. Reactive oxyge

SUBMITTER: Oh J 

PROVIDER: S-EPMC9433722 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature