A genome-wide analysis of 340 318 participants identifies four novel loci associated with the age of first spectacle wear.

ABSTRACT: Refractive errors, particularly myopia, are the most common eye conditions, often leading to serious visual impairment. The age of onset is correlated with the severity of refractive error in adulthood observed in epidemiological and genetic studies and can be used as a proxy in refractive error genetic studies. To further elucidate genetic factors that influence refractive error, we analysed self-reported age of refractive error correction data from the UK Biobank European and perform genome-wide time-to-event analyses on the age of first spectacle wear (AFSW). Genome-wide proportional hazards ratio analyses were conducted in 340 318 European subjects. We subsequently assessed the similarities and differences in the genetic architectures of refractive error correction from different cause

SUBMITTER: Patasova K 

PROVIDER: S-EPMC9433727 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature