The association between ACTB methylation in peripheral blood and coronary heart disease in a case-control study.

ABSTRACT:

Background

Coronary heart disease (CHD) brings a heavy burden to society worldwide. Novel and minimally invasive biomarkers for the risk evaluation of CHD are urgently needed. Previous study has revealed that blood-based hypomethylation of β-actin (ACTB) was associated with increased risk of stroke, but not reported in CHD yet.

Objectives

We aimed to explore the association between blood-based ACTB methylation and the risk of CHD in a case-control study in the Chinese population.

Methods

The methylation level of ACTB was quantitatively determined by mass spectrometry in 281 CHD patients and 272 controls. The association between ACTB methylation and CHD risk was estimated by logistic regression analyses adjusted for possible confounding effe

SUBMITTER: Jin J 

PROVIDER: S-EPMC9433772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature