Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning.

ABSTRACT: Spontaneous bursts in neuronal networks with propagation involving a large number of synchronously firing neurons are considered to be a crucial feature of these networks both in vivo and in vitro. Recently, learning has been shown to improve the association and synchronization of spontaneous events in neuronal networks by promoting the firing of spontaneous bursts. However, little is known about the relationship between the learning phase and spontaneous bursts. By combining high-resolution measurement with a 4,096-channel complementary metal-oxide-semiconductor (CMOS) microelectrode array (MEA) and graph theory, we studied how the learning phase influenced the initiation of spontaneous bursts in cultured networks of rat cortical neurons in vitro. We found that a smal

SUBMITTER: Jia X 

PROVIDER: S-EPMC9433803 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature